Flavay® acts upon your immune system to normalize your body's
balance of chemicals that control inflammation and pain.

Our Customers Say: “ After 7-8 months of burning and pain in my body, two months of taking Flavay® has eliminated it altogether. I have to say I am satisfied with Flavay®.”
—Mr. John H.
Flavay® has been licensed and sold in France for treating inflammation
and edema (swelling) since 1950 and it is now available
in the United States as a dietary supplement. This highly specialized,
nutritional complex of molecules has been isolated from natural extracts
and extensively tested and examined clinically for biological antioxidant
protection, collagen strengthening, tissue rebuilding, and other health
producing outcomes.
Flavay® selectively
binds to the connective tissue of joints, preventing inflammation
and lessening pain.
Our Customers Say: “Flavay® and Flavay Plus® have worked for my rheumatoid arthritis. After two months of taking both, my swelling and pain are gone.”
—Ms. Pat W.
Scientific research shows several ways that Flavay® can stimulate
the immune response to help normalize the balance of chemicals in the
body that control pain and inflammation and normalize joint function.
The "Radical Scavenger" as
a Natural Anti-Inflammatory
Superior Antioxidant Support
Flavay® is superior to other antioxidants because its protective
effects are multiplied in the body. While it provides its own, powerful
antioxidant protection, it also supports the dynamic interplay between
other antioxidants in the body. Flavay’s® ability to recycle,
or regenerate vitamins C and E after they have quenched free radicals
vastly extends their unique antioxidant powers, helping to maintain an
optimal, synergistic antioxidant balance in the body.
Flavay® is rapidly absorbed and very quickly distributed throughout
the body. As a free radical fighter, Flavay® comes to the aid of
the body more quickly than other antioxidants, reducing the potential
for free radical damage and the ravages of aging. Flavay® also possesses
more reactive sites for neutralizing free radicals than other known antioxidants.
Furthermore, Flavay® permits reactivity with both positively and
negatively charged free radical species. What this means is that Flavay®
can quench or scavenge (neutralize) a broad variety
of free radicals. Highly reactive as an antioxidant in both lipid (fat)
and aqueous (water) phases, Flavay® neutralizes oxygen free radicals
and is a valuable protector of healthy cells in a variety of internal
conditions. This is a unique property among antioxidants, as most work
either in lipid or aqueous phases, but not both. As a free radical scavenger,
Flavay®
is like an antioxidant prize fighter that can successfully take on all
challengers, big or small, in any kind of weather
All of this means that your immune system works better so
that your joints hurt less and your blood flows better—with Flavay®.
Our Customers Say: “My elderly mother in China is very frail and was unable to walk due to arthritis pain. I sent Flavay® to her and asked her to try it. After taking 4 Flavay® capsules a day for six months, she is feeling so much better that she is able to walk again! We now hope that all her pain will disappear in time.”
—Ms. M.
Inflammation is caused by the overproduction of free radicals in a specific
area of the body. We now know that antioxidants work together to defeat
free radicals and inhibit the biological pathway that triggers inflammation,
and Flavay® is particularly effective as an anti-inflammatory.
Flavay® can selectively bind to the connective tissue of joints,
preventing inflammation and lessening pain. One of the very first benefits
observed and studied Dr. Jack Masquelier, in as early as 1947, was the
anti-inflammatory effect of Flavay®.
Research demonstrates that Flavay® inhibits the release and synthesis
of histamine (which produces accelerated blood flow, dilates capillaries
and increases their permeability, thereby leaking plasma into surrounding
tissue), a key factor in the promotion of inflammation.
Flavay® inhibits the
release and synthesis of histamine—a key factor in the promotion
of inflammation.
Our Customers Say: “I had terrible pain in my hip and leg for years because of arthritis. It was so bad that I could hardly walk and I could never sleep on the side that hurt. After two weeks of being on Flavay® and Flavay Plus®, like a miracle, my pain is completely gone.”
—Ms. Miriam M.

Studies demonstrate that the anti-histamine action of Flavay® is
obtained through inhibiting the activity of the enzyme histidine decarboxylase.
Dr. Masqueliers research has been confirmed by German studies which
show that Flavay® may lower the production of histamine with as
much as 86% inhibition of histidine decarboxylase.
Flavay® also neutralizes free radicals that promote swelling and
cause inflammation. When joints become arthritic, they become inflamed
and enlarged, interfering with the normal flow of blood. For example,
when you bend an arthritic knee, you cut off blood flow to the area which
sets into motion of a chain of events that will lead to a burst of free
radicals when the blood flow returns (known as "reperfusion injury").
When you release the knee, a proliferation of free radicals causes the
area to become even more inflamed, contributing to the degeneration of
the joint, which becomes more swollen and worn down. Reducing free radicals
eases the swelling associated with inflammation and improves arthritic
condition. Research has shown that a free radical called "superoxide"
is involved in the inflammation of arthritis and experiments demonstrate
that Flavay® quenches the superoxide free radicals. In fact, Flavay®
has been awarded a U.S. patent as a scavenger of the free radicals
that play a major role in the initiation, duration and breakdown of inflammation.
But that's not all it does.
Reducing Edema (Swelling) by
Strengthening Capillary Walls
Edema is an uncomfortable condition and can be both painful and dangerous.
Swollen and painful legs and ankles, puffiness of the eyes and an overall
bloated look and feel are examples of edema. It involves the leakage of
blood serum into surrounding tissues and Flavay® has shown that
it can reduce this leakage by strengthening capillary walls.
All of those taking
Flavay® for edema (swelling) had relief from at least some
of the symptoms.
Italian scientists from the University of Florence studied the effect
of Flavay® on venous congestion (edema) in the legs. The study involved
40 subjects consisting of 13 men and 27 women between the ages of 34 and
74. The subjects were randomly divided into two groups. One group received
a placebo and the other group received 300 mg of Flavay® daily for
60 days.
All of those taking the Flavay® had relief from at least some of
the symptoms. After 30 days, the pain was totally relieved in in 38 percent
of those taking Flavay®, the swelling disappeared in 26 percent
(the circumference of the legs was measured above the ankle), and 11 percent
experienced a decrease in the feeling of heaviness in their lower limbs.
After 60 days, the pain was totally relieved in 67 percent of those taking
Flavay®, the swelling disappeared in 63 percent, and the decrease
in heaviness jumped to 33 percent.
Recovery from Injuries
Soccer players in Australia
experienced significantly less swelling than those who did not
take Flavay®.
Research has shown that Flavay’s® ability to strengthen vascular
walls may help the body to repair injuries faster. In an Australian study
conducted on two groups of soccer players that had sustained injuries,
those that consumed Flavay® for ten days following their injuries
experienced significantly less swelling than those who did not and, in
some of those taking Flavay®, the swelling had completely disappeared.
Other research has demonstrated the ways in which Flavay® may actually
inhibit inflammation including double-blind studies conducted in France
which showed that Flavay® can reduce postoperative inflammation.
Reducing Collagen (Cartilage) Degradation
Arthritis is an umbrella term for more than 100 different conditions
that produce either inflammation of connective tissue (joints and tendons)
or degeneration of the articular (joint) cartilage, a wearing down of
the protective covering that cushions the ends of bones, allowing bones
to rub together without causing damage to the joints.
Collagen is required for the normal functioning of the joints, healthy
cartilage and bones, smooth gliding surfaces, synovial fluid, normal joint
spaces and normal soft tissues surrounding the joints. Collagen is the
building block of connective tissue, veins, arteries, ligaments and tendons,
and every tissue and organ.
Laboratory tests have demonstrated Flavay’s® ability to
reduce degradation of elastin fibers by up to 70 percent.
The nutrients in Flavay® can be considered as 'collagen vitamins'
because they partake in the biosynthesis of collagen and prevent its destruction.
Through synergistic action with vitamin C, Flavay® strengthens and
rebuilds the bodys natural collagen proteins and has the remarkable
ability to reactivate damaged collagen and elastin. Research has demonstrated
that Flavay® binds to collagen fibers and realigns them to a more
youthful, undamaged form. (The same research also established that common
bioflavonoids are completely inactive in this respect.) Flavay® improves
the beneficial cross-linking between the amino acids of the fibers that
give collagen its flexibility and strength while preventing the undesirable
cross-linking between amino acids that weakens collagen. Laboratory tests
have demonstrated Flavay’s®
ability to reduce degradation of elastin fibers by up to 70 percent.
Nitric Oxide Toxicity and Chronic Inflammation
Contemporary research shows
that elevated levels of nitric oxide appear to contribute
to arthritis and other disorders associated to abnormal immune
or inflammatory responses.
Contemporary research shows that elevated levels of nitric oxide (sometimes
referred to as "NO") appear to contribute to arthritis and other
disorders associated to abnormal immune or inflammatory responses. In
the case of arthritis, nitric oxide has been implicated in the destruction
of the pericellular and extracellular matrix of cartilage in arthritis.
When joints become arthritic, they become inflamed and enlarged, interfering
with the normal flow of blood. For example, when you bend an arthritic
knee, you cut off blood flow to the area which sets into motion of a chain
of events that will lead to a burst of free radicals when the blood flow
returns (known as "reperfusion injury"). When you release the
knee, a proliferation of free radicals causes the area to become even
more inflamed, contributing to the degeneration of the joint, which becomes
more swollen and worn down.
It's long been recognized that nitric oxide is essential for normal blood
circulation as it controls the muscular tone of blood vessels and regulates
circulation and blood flow. However, excessive amounts of nitric oxide
can restrict blood flow and promote production of more free radicals,
including the dangerous peroxynitrate.
Our Customers Say: “I have become so free of arthritic pain that I've taken up playing the guitar! I've played a lot today, maybe 4 hours, and as I put away the guitar tonight it occurred to me that without Flavay® I would never be able to do what I've done today.
“My knuckles have shrunk back to normal so I can wear my rings again. Thank you so much for Flavay® and Flavay Plus®!”
—Ms. C. S.
Flavay® can help regulate
a healthy balance of nitric oxide in the body.
Flavay® can significantly scavenge nitric oxide radicals. However,
as we'll discuss next, your body needs a certain amount of nitric oxide
in order to maintain good health. Nitric oxide is paradoxical. Under normal
health conditions, nitric oxide can act as an anti-inflammatory. But to
an already inflamed area, nitric oxide can wreak havoc by causing even
more inflammation. The key, therefore, to normalizing joint function is
to maintain the optimum balance of this double-edged sword, nitric
oxide.
Flavay® and the Nitric Oxide Connection
Nitric oxide is a colorless gas produced by many different cells in the
body that, depending on the situation, can be very good or very
bad. Nitric oxide plays several important roles in the body:
- Nitric oxide is an important signaling molecule that turns genes
on and off.
- By controlling the muscular tone of blood vessels, nitric oxide
regulates the circulation and normalizes blood flow.
- Nitric oxide modulates communication between brain cells and is
instrumental in helping us concentrate and learn new information,
and also in maintaining memory.
- When produced by immune cells, nitric oxide fights infection, kills
tumor cells and promotes wound healing.
- Nitric oxide is essential for perceiving pleasure and pain, and
it helps translate sexual excitement into penile erections.
- Nitric oxide aids in digestion of food by helping to control gastric
movements.
But nitric oxide can be very destructive under other circumstances:
- Nitric oxide restricts blood flow.
- When produced in excess by immune cells, nitric oxide can trigger
chronic inflammation, which can cause arthritis, colitis, inflammatory
bowel disease and possibly cancer.
- Nitric oxide promotes production of more free radicals.
- In the brain, nitric oxide can hamper mental function and cause
memory loss and brain aging.
The real trouble starts when nitric oxide encounters the superoxide free
radical and becomes peroxynitrate, which destroys antioxidants like glutathione,
vitamin E and common flavonoids, and damages proteins in the body. As
long as nitric oxide is produced in the right amount, it remains friendly.
But if nitric oxide is overproduced, the effect can be very toxic. Research
demonstrates that Flavay® can help to maintain the optimal level
of nitric oxide by helping the body to produce adequate levelsand
to neutralize this free radical where it does harm.
U.S. Patent No. 4,698,360
“Radical Scavenger” Effect of Flavay®
Flavay® is the product—used in the actual experiments—by
which Dr. Jack Masquelier established and patented the "Radical
Scavenger Effect."
Flavay’s® strong antioxidant power is patented—as a scavenger
of the free radicals that play a major role in the initiation, duration
and breakdown of inflammation and the degradation of collagen.
"[A] method for preventing and fighting the harmful biological
effects of free radicals in the organism of warm blooded
animals and more especially human beings, namely cerebral involution,
hypoxia following atherosclerosis, cardiac or cerebral infarction,
tumour promotion, inflammation, ischaemia, alterations
of the synovial liquid, collagen degradation, among
others. The method consists in administering to said animals and
especially to human beings an amount, efficient against said effects,
of a plant extract with a proanthocyanidins content which has a
radical scavenger effect"Dr. Jack Masquelier,
U.S. Patent No. 4,698,360.
Our Customers Say: “I've been suffering with carpal tunnel syndrome in both of my wrists for over three years. I also have two active preschoolers, whom I adore, so having carpal tunnel has been really, really painful. My doctor recommended surgery for my wrists but I decided to listen to my brother who suggested that I first try Flavay® and Flavay Plus®. After taking three of each every day for over two months, I no longer have any pain! I can hardly believe it! My kids are happier and so am I because I'm able to take care of them without pain! Thank you so much!”
—Ms. A. S.
Superior Antioxidant Support
Flavay® is superior to other antioxidants because its protective
effects are multiplied in the body. While it provides its own, powerful
antioxidant protection, it also supports the dynamic interplay between
other antioxidants in the body. Flavay’s® ability to recycle,
or regenerate vitamins C and E after they have quenched free radicals
vastly extends their unique antioxidant powers, helping to maintain an
optimal, synergistic antioxidant balance in the body.
Flavay® is rapidly absorbed and very quickly distributed throughout
the body. As a free radical fighter, Flavay® comes to the aid of
the body more quickly than other antioxidants, reducing the potential
for free radical damage and the ravages of aging. Flavay® also possesses
more reactive sites for neutralizing free radicals than other known antioxidants.
Furthermore, Flavay® permits reactivity with both positively and
negatively charged free radical species. What this means is that Flavay®
can quench or scavenge (neutralize) a broad variety
of free radicals. Highly reactive as an antioxidant in both lipid (fat)
and aqueous (water) phases, Flavay® neutralizes oxygen free radicals
and is a valuable protector of healthy cells in a variety of internal
conditions. This is a unique property among antioxidants, as most work
either in lipid or aqueous phases, but not both. As a free radical scavenger,
Flavay®
is like an antioxidant prize fighter that can successfully take on all
challengers, big or small, in any kind of weather
All of this means that your immune system works better so
that your joints hurt less and your blood flows better—with Flavay®.
REFERENCES:
Masquelier, J. Plant extract with
a proanthocyanidins content as a therapeutic agent having radical scavenging
effect and use thereof. U.S. Patent No. 4,698,360, 1987.
Masquelier, J. A lifetime devoted to OPC and pycnogenol. Alfa Omega Editrice,
Pub., 1996.
Schwitters, B., Masquelier, J. OPC in practice. Alfa Omega Editrice, Publishers,
1995.
Kilham, C., Masquelier, J. OPC: The miracle antioxidant. Keats Publishing,
Inc., 1997.
Packer, L., et al. The antioxidant miracle: your complete plan. John Wiley
& Sons, Inc., 1999.
Packer, L., et al. Antioxidant food supplements in human health. Academic
Press, 1999.
Lincoln, J., Hoyle, C.H.V., Burnstock, G., Nitric oxide in health and disease.
Cambridge University Press, 1997.
Moncada, S., Nistico, G., Bagetta, G., Higgs, E.A. Nitric oxide and the
cell. Princeton University Press, 1998.
Facino, R.M., et al. Free radical scavenging action and anti-enzyme activities
of procyanidines from vitis vinifera. A mechanism for their capillary protective
action. Arzneimittelforschung, 44: 592-601, 1994.
Passwater, R.A. The antioxidants: the nutrients that guard your body. Keats
Publishing, Inc., 1985.
Barilla, J. et al. The nutrition superbook: volume 1: the antioxidants.
Keats Publishing, Inc., 1995.
Facino RM, et al. Free radical scavenging action and anti-enzyme activities
of procyanidines from Vitis vinifera. A mechanism for their capillary protective
action. Arzneimittelforschung, 44: 592-601, 1994.
Kuttan R, et al. Collagen treated with catechin becomes resistant to the
action of mammalian collagenase. Experientia, 37: 221-223, 1981.
Masquelier, J., et al. Stabilization du collagene par les oligomeres procyanidoliques.
Acta Therapeutica, 7:101-105, 1981.
Masquelier, J. Aspects pharmacologiques nouveaux de certains flavonoides.
A Vie Medical 12:1969.
Laparra, J., et al. Etude pharmaco-cinetique des oligomers procyandoliques
totaux du raisin. Acta Therapeutica, 4, 1978.
Laparra, J., et al. Etude pharmacocinetique des oligomeres flavonoliques.
Plantes med et phyto, Tome XI, pp. 133-142, 1977.
Robert A.M.; Groult, N.; Six, C.; Robert, L. Etude de laction des
oligomeres procyanidoliques sur des cellules mesenchymateuses en culture.
Ii lattachment des fibres elastiques aux cellules. (Study of the effect
of procyanidolic oligomers on mesenchymal cells in culture. Ii attachment
of elastic fibers to the cells.) Pat Biol, (30)6:601-7, 1990.
Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. The molecular and crystal
structure of (+)-2,3-trans-3,4-trans-leucocyanidin [(2r,3s,+r)-(+)-3,3,
4.4, 5.7-Hexahydroxyflavan] dihydrate, and comparison of its
heterocyclic ring conformation in solution and the solid state. Journal
of the Chemical Society; Perkin Transactions I 1985. pp. 1413-17.
Masquelier, J. Proanthocyanidins et radicaux libres. 1985.
Uchida, S., et al. Condensed tannins scavenge active oxygen free radicals.
Med Sci Res, (15) 1987. pp. 831-832.
Ariga, T. Radical scavenging action and its mode in procyanidins b-1 and
b-3 from azuki beans to peroxyl radicals. Agric Biol Chem, 54(10) 1990.
pp. 2499-2504.
Da Silva, R., et. al. Radical scavenger capacity of different procyanidins
from grape seeds. Presented at a symposium, Free radicals in biotechnology
and medicine. Royal Society Of Chemistry, London January 1990, pp.
79-80.
Bauman, J., Wurm, G., Bruchhausen, F. Hemmung der prostagladinsynthetase
durch flavonoide und phenolderivate im vergleich nit deren 02 radikalfangereigenschaften
Arch Pharm, (Weinheim) 313 (1980) pp. 330-337.
Lombard, J., et al. The brain wellness plan. Kensington Pub. Corp., 1998.
Flesch M., et al., Effects of red and white wine on endothelium-dependent
vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 1998;275:1183-94.
Fitzpatrick, D.F., Fleming R.C., Bing B, Maggi DA, O'Malley RM. Isolation
and characterization of endothelium-dependent vasorelaxing compounds from
grape seeds. J Agr & Food Chem In press.
Fitzpatrick, D.F., Maggi D, Bing B, Coffey RG. Vasorelaxation, endothelium,
and wine. BioFactors 1997;6:455-459.
Fitzpatrick, D.F., Hirschfield SL, Ricci T, Jantzen P, Coffey RG. Endothelium-dependent
vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol
1995;26:90-95.
Fitzpatrick, D.F., Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing
activity of wine and other grape products. Amer J Physiol 1993;265:H774-H778.
Kuttan, R., Donnelly, P.V., Di Ferrante, N. Collagen treated with catechin
becomes resistant to the action of mammalian collagenase. Experientia, 37:
221-223, 1981.
Masquelier, J. Procyanidolic oligomers. J Parums Cosm Arom, 95: 89-97, 1990.
Tixier, J.M., et al. Evidence by in vivo and in vitro studies that binding
of pycnogenol to elastin affects its rate of degradation by elastases.
Biochem Pharmacol, 33: 3933-3939, 1984.
Kakegawa, H., et al. Chem. Pharm. Bull. 33:5079, 1985.
Harmand, M.F., Blanquet, P. The fate of total flavanolic oligomers extracted
from vitus vinifera l. in the rat. European Journal of Drug
Metabolism and Pharmaccokinetics. 1978, No. 1 pp. 15-30.
Delrieu, P., Ding J., Escande, B., Samain, D. Free-radical scavenging activity
of proanthocyanidolic oligomers encapsulated in glycospheres: an in vivo
and in vitro study. Cosmetology Department & S Biovectors, Ramonville
St. Agne France. pp. 1-9.
Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i converting
enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Medica,
May 26, 1986. pp. 12-15.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez lanimal-oedenme de la patte. Sanofi Res Toul Cedex Fr, pp31-40.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez lanimal-activite aniagoniste vis-a-vis des mediateurs de linflamation.
Sanofi Res Toul Cedex Fr, pp. 31-40.
Dubos, C., Durst, G., Hugonot, H. Evolution de la resistance capillaire,
spontanement ou artificiellement diminuee par laction dune substance
capillaro-toxique chez des personnes agees--action benefique dun agnet
actif sur la micro-circulation: lEndotelon. Inform. Therapeut. 1980.
pp. 302-305.
Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude dun
microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7, 1990.
Lagrue, G., Olivier-Martin, F., Grillot, A. Etude des effets des oligomeres
du procyanidol sur las resistance capillaire dand lhypertension arterielle
et certaines nephropathies. Sen. Hosp. Paris 18-25 Septembre, 1981.
Beylot, C., Bioulac, P. Essai therapeutique dun angioprotecteur peripherique,
lEndotelon. Actualite Therapeutique Gaz. Med. de France (87)22:2919-24,
1980.
Lesbre, F.X., Tigaud, J.D. Effect de lEndotelon sur lindice
de fragilite capillaire dan une population specifique: les sujets cirrhotiques.
Gaz. Med. de France, (90)24 1983.
Sarrat, L. Abord therapeutique des troubles fonctionnels des membres inferieurs
par un microangioprotecteur lEndotelon. Bordeaux Med, 11:685-8, 1981.
Delacroix, P. Etude en double aveugle de lEndotelon dans linsuffisance
veineuse chronique. Therapeutique, la Revue de Medicine, (27-28) Sept. 1981.
pp. 1793-1802.
Thebaut, J.F, Thebaut, P., Vin, F. Etude de lEndotelon dand les manifestations
fonctionnelles de linsuffisance veineuse peripherique-resultats dune
etude en double aveugle portant sur 92 patients. Gazette Medicale,
(92)1, 1985. pp. 96-100.
Chang, W.C., Hsu, F.L. Inhibition of platelet aggregation and arachidonate
metabolism in platelets by procyanidins. Prostagland Leukotri Essent Fatty
Acids, 38:181-8, 1989.
Masquelier, J. pycnogenol: recent advances in the therapeutical activity
of procyanidins. Supplement of Planta Medica, Journal of Medicinal Plant
Research and Journal of Natural Products, July 1980 pp. 243-256.
Henning, B., et al. Lipid peroxidation and endothelial cell injury: implications
in atherosclerosis. Free Rad Path & Med, (4)1988 pp. 99-106.
Masquelier, J. Les procyanidols du vin leur role dans lalcoolisme.
pp. 88-93.
Gazave, J.M. Notions recentes sur les capillaires unpub. bulletin
from the Laboratoire De Physiologie Patholigie pp. 26-29.
Ruf, J.C. Wine and polyphenols related to platelet aggregation and atherothrombosis.
Office International Vigne et du Vin, Nutrition and Health Unit, Paris France;
Drugs under Experimental and Clinical Research (Switz.) 25/2-3 (125-131),
1999.
Blaszo, G. Gabor, M. Oedema-inhibiting effect of procyanidin. Acta Physiologica
Academiae Scientiarum Hungaricae, Tomus 56(2):235-240, 1980.
Tayau, M.F, LeFevre, G. Action du leucocyanidol sur lhyalaluronidase.
Bull Soc Pharm Bordeaux, 95:132-136, 1956.
Lamy, M. Utilization des oligomeres procyanidoliques en gynecologie. Essai
Therapeutique Tomel (14) Sept. 2, 1981. pp. 1021-22.
Henriet, J.P Une Etude Exemplaire Pour Un Phlebotrope: letude
EIVE. Unpub., pp. 77-83.
Pfister, A., Simon, M.T., Gazave, J.M. Sites de fixation des oligomeres
procyanidoliques dans la paroi des capillaires sanguins du poumon decobaye.
Acta Therapeutica (8) 1982. pp. 223-237.
Kuttan, R., Donnelly, P., Di Ferrante, N. Collagen treated with (+)
-catechin becomes resistant to the action of mammalian collagenase.
Laboratory of Connective Tissue Research, Dept. of Biochem. Baylor Col.
of Med., Houston TX. 28, May, 1980.
Gendre, P., Laparra, J., Barraud, E. Effect protecteur des oligomeres
procyanidoliques sur le lathyrisme experimental chez le rat. Ann.
Pharm. Francaises, (43)1, 1985 pp. 61-73.
Corbe, C., Boissin, J.P., Siou, A. Light vision and chorioretinal circulation.
Study of the effect of procyanidolic oligomer (Endotelon). Jn. Fr. Opthalmol,
(11)5:453-460, 1988.
Boissin, J.P., Corbe C., Siou, A. Chorioretinal circulation and dazzling:
use of procyanidol oligomers (Endotelon). Bull Soc Ophtalmol Fr, 88(2):173-4,
177-9, 1988.
Proto, F. et al. Electrophysical study of vitis vinifera procyanoside oligomers
effects on retinal function in myopic subjects. Ann Ott Clin Ocul, 114:85-93,
1988.
Saracco, J.B., Estachy, G.M. Etude d lEndotelon en opthalmologie.
Gaz Med de France, 88:2035-2038, 1981.
Scharrer, A., Ober, M. Anthocyanosides in the treatment of retinopathies.
Klin Monatsbl Augenheilkd, 178:386-389, 1981.
Corbe, C., et al. Microangiopathy of the retina. J. Fr. Opthalmol, 11:453,
1988.
Verin, M.M., Vildy, A., Maurin, J.F., Retinopathies et O.P.C. Bordeaux Medicale,
(16)11. pp. 1467-74, 1978.
Soyeux, A. et al. Endotelon. Diabetic retinopathy and hemorheology. Bull
Soc Ophtalmol Fr. 87(12):1441-4, 1987.
Fromantin, M. Les oligomeres procyanidoliques dans le traitement de
la fragilite capillaire et de la retinopathie chez les diabetiques. A propos
de 26 cas. Med Int, 16(11):432-434, Nov. 1981.
Arne, J.L. Contribution a letude des oligomeres procyanidoliques:
Endotelon, dans la retinopathie diabetique (a propos de 30 observations).
Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982.
Baruch, J. Effect of Endotelon in postoperative edema. Results of a double-blind
study versus placebo in 32 female patients. Ann Chir Plast Esthet 29(4):393-5,
1984.
Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism in
rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62, 1981.
Gabor, M. Pharmacologic effects of flavonoids on blood vessels. Angiologica,
9:355-374, 1972.
Havsteen, B. Flavonoids, a class of natural products of high pharmacological
potency. Biochem Pharmacol, 32:1141-48, 1983.
Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.J. Berkhauser
Verlag, Vol. 7/1, Univ. of Marburg/Lahn, Ger., 1977.
Masquelier, J. Action protectrice du vin sur lulcere gastrique. Resultats,
p. 61.
Amella, M., et al. Inhibition of mast cell histamine release by flavonoids
and bioflavonoids. Planta Medica, 5116-20, 1985.
Shaw, R. How [Australian] PycnoGenol [MASQUELIERs®] Helps Sports
People.
Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums Cosmet
Arom 95:89-97, 1990.
Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques
(Endotelon) dans le traitement des lymphoedemes post-therepeutiques de members
superieurs. Symposium Satellite, Congres International dAngiologie,
Toulouse, France, 4-7 Oct. 1989.
Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during 2 weeks
of intense training. Abstract submitted to national meeting of the Amer
College of Sports Medicine, June 1998.
Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. Blunting by
chronic phosphatidylserine administration of the stress-induced activation
of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm
43: 385388, 1992.
Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine
administration during two weeks of resistive exercise-induced overtraining.
Bio of Sport 15(3):135-44, 1998.
Laparra, J., Michaud, J. Masquelier, J. Action des oligomeres procyanidoliques
sur le cobaye carence en vitamin c. Tavaux Originaux, University of Bordeaux,
1976.
Masquelier, J. Action comparee de divers facteurs vitaminiques p sur loxydation
de lacide ascorbique par les ions cuivriques. Bull. de la Societe
de Chimie Biologique XXXIII (3-4) 1951. pp. 302-304.
Masquelier, J. Action comparee de divers facteurs vitaminiques p sur lacide
ascorbique-oxydase. Bull. de la Societe de Chimie Biologique XXXIII (3,4)
1951. pp.304-306
Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T., Nonaka, G., Mishioka,
I. Inhibitory effects of tannins on hyaluronidase activation and on
the degranulation from rat mesentery mast cells. Chem. Pharm. Bull.
33(11)1985. 5079-5082.
Reiman, H.J., Lorenz, M., Fischer, R., Frolich, H., Meyer, J. Histamine
and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress
ulcer formulation by (+)-catechin, an inhibitor of specific histidine decarboxylase
in vitro. Dirkhauser Verlag,Vol. 7/1, 1977.
Pariente, J.J. Parientl-Amsellem, J. Les oedemes post-traumatoqies
chez le sportif: essai controle de lEndothelon. Actualite Therapeutique
90(3) 2/11 1983 pp. 231-235.
Masquelier, J., et al. Flavonoids et pycnogenol Int J Vit Nut
Res, (49)3:307-311, 1979.
Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol.
25(2):135-9, 1987.
Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica
Report, 1971.
Laparra, J., et al., Acta Therapeutica, 4:233, 1978.
Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow cells
of the mouse with Pycnogenol. Cytotest Cell Research GmbH & Co., projects
143010 & 143021; Feb. 1989.
Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover,
Germany, 1967-1971.
Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in vegetable
extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux,
129:51-65, 1990.